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Version: 17.06d (Release date: 2017-06-26)
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Hafnium Oxide-containing Nanoparticles NBTXR3 (Code C98280)

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Terms & Properties

Preferred Name: Hafnium Oxide-containing Nanoparticles NBTXR3

Definition: A suspension of nanoparticles containing inert inorganic hafnium oxide (HfO2) crystals with potential antineoplastic activity. Upon injection of NBTXR3 in the tumor, the hafnium oxide-containing nanoparticles accumulate into the tumor cells. Subsequent application of radiation beams to the tumor tissue causes HfO2 particles to emit huge amounts of electrons. This results in the formation of free radicals within the tumor cells, which in turn causes targeted destruction of the cancer cells. Compared to standard radiotherapy, because of the inert nature of NBTXR3, this agent emits electrons only during its exposure to radiation which improves radiotherapy efficiency.

Display Name: Hafnium Oxide-containing Nanoparticles NBTXR3

Label: Hafnium Oxide-containing Nanoparticles NBTXR3

NCI Thesaurus Code: C98280 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL432399  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Hafnium Oxide-containing Nanoparticles NBTXR3
NBTXR3

External Source Codes: 
PDQ Closed Trial Search ID 712103
PDQ Open Trial Search ID 712103 (check for NCI PDQ open clinical trial info)
NCI META CUI CL432399

Other Properties:
     Name Value (qualifiers indented underneath)
code C98280
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C98280

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