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Version: 17.08d (Release date: 2017-08-28)
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Chloroquinoxaline Sulfonamide (Code C982)

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Terms & Properties

Preferred Name: Chloroquinoxaline Sulfonamide

Definition: A chlorinated heterocyclic sulfanilamide with potential antineoplastic activity and potential immunosuppressive activity. Chloroquinoxaline sulfonamide poisons topoisomerase II alpha and topoisomerase II beta, thereby causing double-stranded breaks in DNA, accumulation of unrepaired DNA, and apoptosis. This agent also exhibits lymphotoxicity by inhibiting lymphocyte activation in a cell cycle-specific manner. (NCI04)

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It is a type of topoisomerase inhibitor.

Label: Chloroquinoxaline Sulfonamide

NCI Thesaurus Code: C982 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0049111  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Benzenesulfonamide, 4-amino-N-(5-chloro-2-quinoxalinyl)-
Benzenesulfonamide, 4-amino-N-[5-chloro-2-quinoxalinyl]-
chloroquinoxaline sulfonamide
Chloroquinoxaline Sulfonamide
Chloroquinoxaline sulfonamide

External Source Codes: 
CAS Registry Number 97919-22-7 (see NLM ChemIDplus info)
NSC Code 339004 (see NCI DTP info)
PDQ Closed Trial Search ID 41055
PDQ Open Trial Search ID 41055 (check for NCI PDQ open clinical trial info)
UMLS CUI C0049111

Other Properties:
     Name Value (qualifiers indented underneath)
code C982
Legacy_Concept_Name Chloroquinoxaline_Sulfonamide
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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