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Version: 17.06d (Release date: 2017-06-26)
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Decitabine (Code C981)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Decitabine

Definition: A cytidine antimetabolite analogue with potential antineoplastic activity. Decitabine incorporates into DNA and inhibits DNA methyltransferase, resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. (NCI04)

NCI-GLOSS Definition: A drug that is used to treat myelodysplastic syndromes and is being studied in the treatment of other types of cancer. It is a type of antimetabolite.

Display Name: Decitabine

Label: Decitabine

NCI Thesaurus Code: C981 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0049065  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2'-Deoxy-5-azacytidine
4-Amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one
5-Aza-2'-deoxycytidine
5-Aza-2'deoxycytidine
5-Aza-2-deoxycytidine
5-Azadeoxycytidine
Dacogen
Decitabine
decitabine
DECITABINE
Decitabine for Injection
Deoxyazacytidine
Dezocitidine

External Source Codes: 
CAS Registry Number 2353-33-5 (see NLM ChemIDplus info)
FDA UNII Code 776B62CQ27
ChEBI ID CHEBI:50131 (see ChEBI info)
NSC Code 127716 (see NCI DTP info)
PDQ Closed Trial Search ID 39299
PDQ Open Trial Search ID 39299 (check for NCI PDQ open clinical trial info)
UMLS CUI C0049065

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Myelodysplastic Syndrome
Chemical_Formula C8H12N4O4
code C981
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Decitabine
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C981

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