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Version: 17.06d (Release date: 2017-06-26)
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Dihydro-5-Azacytidine (Code C980)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Dihydro-5-Azacytidine

Definition: A synthetic nucleoside analogue of deoxycytidine. Dihydro-5-azacytidine inhibits DNA methyltransferase, thereby interfering with abnormal DNA methylation patterns that are associated with genetic instability in some tumor cells. Inhibition of this enzyme may restore expression of tumor-suppressor genes and result in antitumor activity. (NCI04)

Display Name: Dihydro-5-Azacytidine

Label: Dihydro-5-Azacytidine

NCI Thesaurus Code: C980 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0048906  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,3,5-triazin-2(1H)-one, 4-amino-3, 6-dihydro-1-beta-D-ribofuranosyl monohydrochloride
5,6-DIHYDRO-5-AZACYTIDINE
5,6-dihydro-5-azacytidine HCl
5,6-Dihydro-5-azacytidine hydrochloride
5,6-dihydro-5-azacytidine hydrochloride
DHAC
Dihydro-5-Azacytidine

External Source Codes: 
CAS Registry Number 62488-57-7 (see NLM ChemIDplus info)
FDA UNII Code 0627D8VG1C
NSC Code 264880 (see NCI DTP info)
PDQ Closed Trial Search ID 39220
PDQ Open Trial Search ID 39220 (check for NCI PDQ open clinical trial info)
UMLS CUI C0048906

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C8H14N4O5
code C980
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Dihydro-5-Azacytidine
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C980

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