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Version: 17.06d (Release date: 2017-06-26)
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Immunocytokine NHS-IL12 (Code C97961)

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Terms & Properties

Preferred Name: Immunocytokine NHS-IL12

Definition: A fusion protein consisting of the heavy-chains of the human antibody NHS76, raised against DNA released by necrotic tumor cells, and fused to two molecules of a genetically modified human interleukin-12 (IL-12) with potential immunostimulating and antineoplastic activities. Upon administration, the antibody moiety of immunocytokine NHS-IL12 binds to DNA released from necrotic tumor cells located primarily at the core of necrotic solid tumors, thereby delivering the IL-12 moiety. In turn, the IL-12 moiety of this agent stimulates the host immune system to mount an immune response against tumor cells, thereby inhibiting tumor growth. IL-12 is a proinflammatory cytokine with numerous immunoregulatory functions and may augment host immune responses to tumor cells. By targeting tumor cells, NHS-IL-12 may reduce the toxicity associated with systemic administration of recombinant human IL-12.

Display Name: Immunocytokine NHS-IL12

Label: Immunocytokine NHS-IL12

NCI Thesaurus Code: C97961 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3273725  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Immunocytokine NHS-IL12

External Source Codes: 
PDQ Closed Trial Search ID 710539
PDQ Open Trial Search ID 710539 (check for NCI PDQ open clinical trial info)
UMLS CUI C3273725

Other Properties:
     Name Value (qualifiers indented underneath)
code C97961
Contributing_Source CTRP
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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