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Version: 16.11d (Release date: 2016-11-28)
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Adenovirus-mediated Human Interleukin-12 INXN-2001 Plus Activator Ligand INXN-1001 (Code C97959)

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Terms & Properties

Preferred Name: Adenovirus-mediated Human Interleukin-12 INXN-2001 Plus Activator Ligand INXN-1001

Definition: A replication incompetent adenovirus encoding the human pro-inflammatory cytokine interleukin-12 (IL-12) (INXN-2001) in combination with the proprietary activator ligand INXN-1001, with potential immunomodulating and antineoplastic activities. Production of IL-12 is controlled by an inducible DNA element that allows transcription initiation only in the presence of the ligand inducer. Upon intratumoral administration of INXN-2001 and oral administration of INXN-1001, INXN-1001 is able to induce expression of IL-12 from INXN-2001. IL-12 expressed by the adenovirus may activate the immune system by promoting the activation of natural killer cells (NKs), inducing secretion of interferon-gamma and inducing cytotoxic T cell responses against tumor cells, which may result in immune-mediated tumor cell death and inhibition of tumor cell proliferation.

Display Name: Adenovirus-mediated Human Interleukin-12 INXN-2001 Plus Activator Ligand INXN-1001

Label: Adenovirus-mediated Human Interleukin-12 INXN-2001 Plus Activator Ligand INXN-1001

NCI Thesaurus Code: C97959 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL430563  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ad-RTS-IL-12 Plus AL
Adenovirus-mediated Human Interleukin-12 INXN-2001 Plus Activator Ligand INXN-1001
INXN-2001/1001
ZIN ATI-001

External Source Codes: 
PDQ Closed Trial Search ID 710508
PDQ Open Trial Search ID 710508 (check for NCI PDQ open clinical trial info)
NCI META CUI CL430563

Other Properties:
Name Value (qualifiers indented underneath)
code C97959
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C97959

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