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Version: 17.12d (Release date: 2017-12-26)
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VEGFR2 Tyrosine Kinase Inhibitor PF-00337210 (Code C97950)

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Terms & Properties

Preferred Name: VEGFR2 Tyrosine Kinase Inhibitor PF-00337210

Definition: An orally available ATP-competitive inhibitor of the vascular endothelial growth factor receptor type 2 (VEGFR2), with potential anti-angiogenesis and antineoplastic activities. Upon administration, the VEGFR2 tyrosine kinase inhibitor PF-00337210 selectively binds to VEGFR2 and prevents its phosphorylation which may result in an inhibition of migration, proliferation and survival of endothelial cells, microvessel formation, the inhibition of tumor cell proliferation, and may eventually cause tumor cell death. VEGFR2, a receptor tyrosine kinase, is frequently overexpressed by a variety of tumor types.

Display Name: VEGFR2 Tyrosine Kinase Inhibitor PF-00337210

Label: VEGFR2 Tyrosine Kinase Inhibitor PF-00337210

NCI Thesaurus Code: C97950 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3253799  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
VEGFR2 Tyrosine Kinase Inhibitor PF-00337210

External Source Codes: 
PDQ Closed Trial Search ID 709389
PDQ Open Trial Search ID 709389 (check for NCI PDQ open clinical trial info)
UMLS CUI C3253799

Other Properties:
     Name Value (qualifiers indented underneath)
code C97950
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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