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Version: 16.11d (Release date: 2016-11-28)
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Henatinib Maleate (Code C97949)

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Terms & Properties

Preferred Name: Henatinib Maleate

Definition: The maleate salt form of henatinib, an orally bioavalable, multitargeted tyrosine kinase inhibitor with potential antitumor and antiangiogenic activities. Henatinib inhibits vascular endothelial growth factor receptor type 2 (VEGFR2), a tyrosine kinase receptor upregulated in many tumor cells that plays a key role in angiogenesis. This may result in an inhibition of angiogenesis and eventually tumor cell proliferation. Henatinib, structurally similar to sunitinib, also inhibits, though to a lesser extent, mast/stem cell growth factor receptor (c-Kit) and, platelet-derived growth factor receptor (PDGFR) alpha and beta.

Label: Henatinib Maleate

NCI Thesaurus Code: C97949 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2935073  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(R,Z)-2-[(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene) methyl]-5-(2-hydroxy-3-morpholinopropyl)-3-methyl-5,6,7,8-tetrahydro-1H-pyrrolo[3,2-c] azepin-4-ketone Maleate
Henatinib Maleate

External Source Codes: 
PDQ Closed Trial Search ID 709376
PDQ Open Trial Search ID 709376 (check for NCI PDQ open clinical trial info)
UMLS CUI C2935073

Other Properties:
Name Value (qualifiers indented underneath)
code C97949
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C97949

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