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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Certolizumab (Code C97947)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Certolizumab

Definition: A Fab fragment of a recombinant, humanized monoclonal antibody directed against the proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha), with anti-inflammatory activity. Upon administration, certolizumab binds to TNF-alpha, preventing the interaction of this cytokine with endogenous cell surface receptors, thereby rendering TNF-alpha inactive and inhibiting TNF-mediated inflammatory responses. TNF-alpha is a protein involved in inflammation, cell survival, and apoptosis.

Label: Certolizumab

NCI Thesaurus Code: C97947 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL430555  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CERTOLIZUMAB
Certolizumab

External Source Codes: 
FDA UNII Code G6ADW90R16
NCI META CUI CL430555

Other Properties:
     Name Value (qualifiers indented underneath)
code C97947
Contributing_Source FDA
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C97947

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