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Version: 17.06d (Release date: 2017-06-26)
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Cabozantinib S-malate (Code C97938)

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Terms & Properties

Preferred Name: Cabozantinib S-malate

Definition: The s-malate salt form of cabozantinib, an orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Cabozantinib strongly binds to and inhibits several RTKs, which are often overexpressed in a variety of cancer cell types, including hepatocyte growth factor receptor (MET), RET (rearranged during transfection), vascular endothelial growth factor receptor types 1 (VEGFR-1), 2 (VEGFR-2), and 3 (VEGFR-3), mast/stem cell growth factor (KIT), FMS-like tyrosine kinase 3 (FLT-3), TIE-2 (TEK tyrosine kinase, endothelial), tropomyosin-related kinase B (TRKB) and AXL. This may result in an inhibition of both tumor growth and angiogenesis, and eventually lead to tumor regression.

Display Name: Cabozantinib S-malate

Label: Cabozantinib S-malate

NCI Thesaurus Code: C97938 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3181684  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Butanedioic acid, 2-hydroxy-, (2S)-, compd. with N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)
Cabozantinib S-malate

External Source Codes: 
CAS Registry Number 1140909-48-3 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 461103
PDQ Open Trial Search ID 461103 (check for NCI PDQ open clinical trial info)
UMLS CUI C3181684

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C28H24FN3O5.C4H6O5
code C97938
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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