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Version: 16.11d (Release date: 2016-11-28)
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Ruxolitinib Phosphate (Code C97937)

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Terms & Properties

Preferred Name: Ruxolitinib Phosphate

Definition: The phosphate salt form of ruxolitinib, an orally bioavailable Janus-associated kinase (JAK) inhibitor with potential antineoplastic and immunomodulating activities. Ruxolitinib specifically binds to and inhibits protein tyrosine kinases JAK 1 and 2, which may lead to a reduction in inflammation and an inhibition of cellular proliferation. The JAK-STAT (signal transducer and activator of transcription) pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies.

Display Name: Ruxolitinib Phosphate

Label: Ruxolitinib Phosphate

NCI Thesaurus Code: C97937 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3247913  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(3R)-3-cyclopentyl-3-(4-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)pyrazol-1-yl)propanenitrile Phosphate (1:1)
1H-Pyrazole-1-propanenitrile, beta-cyclopentyl-4-(7H-pyrrolo(2,3-d)pyrimidin-4-yl)-,(betaR)-, phosphate (1:1)
INCB-18424 Phosphate
Jakafi
Ruxolitinib Phosphate
RUXOLITINIB PHOSPHATE

External Source Codes: 
CAS Registry Number 1092939-17-7 (see NLM ChemIDplus info)
FDA UNII Code 436LRU32H5
PDQ Closed Trial Search ID 593437
PDQ Open Trial Search ID 593437 (check for NCI PDQ open clinical trial info)
UMLS CUI C3247913

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C17H18N6H3O4P
code C97937
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C97937

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