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Version: 17.06d (Release date: 2017-06-26)
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PI3K Alpha/mTOR Inhibitor PWT33597 Mesylate (Code C97915)

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Terms & Properties

Preferred Name: PI3K Alpha/mTOR Inhibitor PWT33597 Mesylate

Definition: The mesylate salt form of PWT33597, an orally bioavailable dual inhibitor of phosphatidylinositide 3-kinase (PI3K) alpha and mammalian target of rapamycin (mTOR) kinase with potential antineoplastic activity. PI3K alpha/mTOR dual inhibitor PWT33597 selectively inhibits both PI3K alpha kinase and mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in PI3K/mTOR-overexpressing tumor cells. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K.

Display Name: PI3K Alpha/mTOR Inhibitor PWT33597 Mesylate

Label: PI3K Alpha/mTOR Inhibitor PWT33597 Mesylate

NCI Thesaurus Code: C97915 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL430398  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
PI3K Alpha/mTOR Inhibitor PWT33597 Mesylate
PWT33597 Mesylate

External Source Codes: 
PDQ Closed Trial Search ID 708121
PDQ Open Trial Search ID 708121 (check for NCI PDQ open clinical trial info)
NCI META CUI CL430398

Other Properties:
     Name Value (qualifiers indented underneath)
code C97915
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C97915

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