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Version: 17.06d (Release date: 2017-06-26)
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Lometrexol (Code C979)

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Terms & Properties

Preferred Name: Lometrexol

Definition: A folate analog antimetabolite with antineoplastic activity. As the 6R diastereomer of 5,10-dideazatetrahydrofolate, lometrexol inhibits glycinamide ribonucleotide formyltransferase (GARFT), the enzyme that catalyzes the first step in the de novo purine biosynthetic pathway, thereby inhibiting DNA synthesis, arresting cells in the S phase of the cell cycle, and inhibiting tumor cell proliferation. The agent has been shown to be active against tumors that are resistant to the folate antagonist methotrexate. (NCI04)

NCI-GLOSS Definition: A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called antifolates.

Label: Lometrexol

NCI Thesaurus Code: C979 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0048852  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(6R)-DDATHF
6R-5,10-Dideazatetrahydrofolate
L-Glutamic acid, N-(4-(2-((6R)-2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-d)pyrimidin-6-yl)ethyl)benzoyl)-
L-Glutamic acid, N-(4-(2-(2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-d)pyrimidin-6-yl)ethyl)benzoyl)-, (R)-
LOMETREXOL
Lometrexol
lometrexol
Pyrido[2,3-d]pyrimidine, L-glutamic acid derivative (9CI)

External Source Codes: 
CAS Registry Number 106400-81-1 (see NLM ChemIDplus info)
FDA UNII Code 6P3AVY8A7Q
NSC Code 660025 (see NCI DTP info)
PDQ Closed Trial Search ID 41670
PDQ Open Trial Search ID 41670 (check for NCI PDQ open clinical trial info)
UMLS CUI C0048852

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C21H25N5O6
code C979
Contributing_Source FDA
Legacy_Concept_Name Lometrexol
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C979

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