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Version: 17.06d (Release date: 2017-06-26)
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Doxifluridine (Code C978)

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Terms & Properties

Preferred Name: Doxifluridine

Definition: A fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by dihydropyrimidine dehydrogenase in the gut wall, is converted into 5-FU in the presence of pyrimidine nucleoside phosphorylase. 5-FU interferes with DNA synthesis and subsequent cell division by reducing normal thymidine production and interferes with RNA transcription by competing with uridine triphosphate for incorporation into the RNA strand.

Label: Doxifluridine

NCI Thesaurus Code: C978 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0048808  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
5'-Deoxy-5-fluorouridine
5-DFUR
DOXIFLURIDINE
Doxifluridine

External Source Codes: 
CAS Registry Number 3094-09-5 (see NLM ChemIDplus info)
FDA UNII Code V1JK16Y2JP
PDQ Closed Trial Search ID 481255
PDQ Open Trial Search ID 481255 (check for NCI PDQ open clinical trial info)
UMLS CUI C0048808

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C9H11FN2O5
code C978
Contributing_Source FDA
Legacy_Concept_Name Doxifluridine
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C978

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