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Version: 17.06d (Release date: 2017-06-26)
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Doxifluridine (Code C978)

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Terms & Properties

Preferred Name: Doxifluridine

Definition: A fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by dihydropyrimidine dehydrogenase in the gut wall, is converted into 5-FU in the presence of pyrimidine nucleoside phosphorylase. 5-FU interferes with DNA synthesis and subsequent cell division by reducing normal thymidine production and interferes with RNA transcription by competing with uridine triphosphate for incorporation into the RNA strand.

Label: Doxifluridine

NCI Thesaurus Code: C978 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0048808  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 3094-09-5 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 481255
PDQ Open Trial Search ID 481255 (check for NCI PDQ open clinical trial info)
UMLS CUI C0048808

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C9H11FN2O5
code C978
Contributing_Source FDA
Legacy_Concept_Name Doxifluridine
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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