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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Microtubule-targeted Agent BAL101553 (Code C97664)

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Terms & Properties

Preferred Name: Microtubule-targeted Agent BAL101553

Definition: An orally available, highly water-soluble lysine prodrug of the synthetic small molecule BAL27862 with potential antitumor activity. Upon administration of BAL101553 and conversion into the active form BAL27862, this agent binds to tubulin at a site distinct from the vinca-alkaloid-binding site, and prevents tubulin polymerization and destabilizes microtubules, ultimately leading to cell cycle arrest, blockage of cell division and an induction of cell death in cancer cells.

Display Name: Microtubule-targeted Agent BAL101553

Label: Microtubule-targeted Agent BAL101553

NCI Thesaurus Code: C97664 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3273554  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Microtubule-targeted Agent BAL101553

External Source Codes: 
PDQ Closed Trial Search ID 706747
PDQ Open Trial Search ID 706747 (check for NCI PDQ open clinical trial info)
UMLS CUI C3273554

Other Properties:
     Name Value (qualifiers indented underneath)
code C97664
Contributing_Source CTRP
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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