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Version: 17.12d (Release date: 2017-12-26)
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Lisavanbulin (Code C97664)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Lisavanbulin

Definition: An orally available, highly water-soluble lysine prodrug of the synthetic small molecule BAL27862 with potential antitumor activity. Upon administration of lisavanbulin and conversion into the active form BAL27862, this agent binds to tubulin at a site distinct from the vinca-alkaloid-binding site, and prevents tubulin polymerization and destabilizes microtubules, ultimately leading to cell cycle arrest, blockage of cell division and an induction of cell death in cancer cells.

Display Name: Lisavanbulin

Label: Lisavanbulin

NCI Thesaurus Code: C97664 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3273554  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(2S)-2,6-Diamino-N-(4-(2-(2-(4-((2-cyanoethyl)amino)-1,2,5-oxadiazol-3-yl)-1H-benzimidazol-1-yl)acetyl)phenyl)hexanamide
BAL-101553
BAL101553
Lisavanbulin
LISAVANBULIN

External Source Codes: 
CAS Registry Number 1263384-43-5 (see NLM ChemIDplus info)
FDA UNII Code 5PT0QP06X5
PDQ Closed Trial Search ID 706747
PDQ Open Trial Search ID 706747 (check for NCI PDQ open clinical trial info)
UMLS CUI C3273554

Other Properties:
     Name Value (qualifiers indented underneath)
code C97664
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97664

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