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Version: 17.06d (Release date: 2017-06-26)
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Gallium Ga 68-DOTATATE (Code C97661)

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Terms & Properties

Preferred Name: Gallium Ga 68-DOTATATE

Definition: A radioconjugate consisting of the somatostatin analogue tyrosine-3-octreotate (Tyr3-octreotate or TATE) labeled with the positron emission tomography (PET) tracer gallium Ga 68 via the macrocyclic chelating agent dodecanetetraacetic acid (DOTA), which may be used as a somatostatin receptor (SSTR) imaging agent in conjunction with PET to image neuroendocrine tumors (NETs). Gallium Ga 68-DOTATATE binds to SSTRs, with a much higher affinity for type 2 SSTR, present on the cell membranes of many types of NETs. This allows for visualization of SSTR-positive cells upon imaging. SSTR subtypes have been shown to be present in large numbers on NETs and their metastases, while most other normal tissues express low levels of SSTR subtypes.

Display Name: Gallium Ga 68-DOTATATE

Label: Gallium Ga 68-DOTATATE

NCI Thesaurus Code: C97661 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1742831  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(68)Ga-DOTA-TATE
68Ga-DOTATATE
Gallium-68 DOTA-DPhe1, Tyr3-octreotate
Gallium Ga 68-DOTATATE

External Source Codes: 
PDQ Closed Trial Search ID 706490
PDQ Open Trial Search ID 706490 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 19662413 (see PubMed Primary Reference info)
UMLS CUI C1742831

Other Properties:
     Name Value (qualifiers indented underneath)
code C97661
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C97661

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