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Version: 17.06d (Release date: 2017-06-26)
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MET Tyrosine Kinase Inhibitor SAR125844 (Code C97511)

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Terms & Properties

Preferred Name: MET Tyrosine Kinase Inhibitor SAR125844

Definition: An inhibitor of the proto-oncogene c-Met (also known as hepatocyte growth factor receptor (HGFR)) with potential antineoplastic activity. Upon intravenous administration, c-Met inhibitor SAR125844 binds to c-Met, thereby disrupting c-Met-mediated signal transduction pathways. This may result in cell growth inhibition in tumors that overexpress c-Met. c-Met, a receptor tyrosine kinase overexpressed or mutated in a variety of cancers, plays an important role in tumor cell proliferation, survival, invasion, metastasis and tumor angiogenesis.

Display Name: MET Tyrosine Kinase Inhibitor SAR125844

Label: MET Tyrosine Kinase Inhibitor SAR125844

NCI Thesaurus Code: C97511 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3273459  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
MET Tyrosine Kinase Inhibitor SAR125844
SAR125844

External Source Codes: 
PDQ Closed Trial Search ID 703771
PDQ Open Trial Search ID 703771 (check for NCI PDQ open clinical trial info)
UMLS CUI C3273459

Other Properties:
     Name Value (qualifiers indented underneath)
code C97511
Contributing_Source CTRP
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C97511

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