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Version: 17.06d (Release date: 2017-06-26)
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CCR2 Antagonist PF-04136309 (Code C97507)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: CCR2 Antagonist PF-04136309

Definition: An orally available human chemokine receptor 2 (CCR2) antagonist with potential immunomodulating and antineoplastic activities. Upon oral administration, CCR2 antagonist PF-04136309 specifically binds to CCR2 and prevents binding of the endothelium-derived chemokine ligand CLL2 (monocyte chemoattractant protein-1 or MCP1) to its receptor CCR2, which may result in inhibition of CCR2 activation and signal transduction. This may inhibit inflammatory processes as well as angiogenesis, tumor cell migration, and tumor cell proliferation. The G-protein coupled receptor CCR2 is expressed on the surface of monocytes and macrophages, stimulates the migration and infiltration of these cell types, and plays an important role in inflammation, angiogenesis, and tumor cell migration and proliferation.

Display Name: CCR2 Antagonist PF-04136309

Label: CCR2 Antagonist PF-04136309

NCI Thesaurus Code: C97507 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL430252  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CCR2 Antagonist PF-04136309
PF-04136309

External Source Codes: 
PDQ Closed Trial Search ID 703421
PDQ Open Trial Search ID 703421 (check for NCI PDQ open clinical trial info)
NCI META CUI CL430252

Other Properties:
     Name Value (qualifiers indented underneath)
code C97507
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C97507

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