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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Interferon Alpha 2b-like Protein (Code C97503)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Recombinant Interferon Alpha 2b-like Protein

Definition: A proprietary recombinant protein highly resembling human interferon alpha 2b (IFN-a2b), with potential anti-tumor, anti-inflammatory, immunomodulating and antiviral activities. Upon injection, recombinant IFN alpha 2b-like protein binds to specific IFN alpha cell surface receptors. This activates interferon-mediated signal transduction pathways and induces the transcription and translation of genes with interferon-specific response elements (ISREs). This may activate the immune system, including the activation of natural killer cells (NKs) and may result in an inhibition of tumor cell proliferation, tumor angiogenesis, metastasis and an induction of apoptosis. Compared to human IFN-a2b (HuINF-a2b), this agent exhibits enhanced antiviral and antiproliferative activities. In addition, this agent exhibits antiviral activity against a variety of viruses, including hepatitis B and C viruses, human immunodeficiency virus (HIV) and Avian Influenza.

Label: Recombinant Interferon Alpha 2b-like Protein

NCI Thesaurus Code: C97503 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL430249  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Novaferon
Recombinant IFN Alfa-2b-like Protein
Recombinant Interferon Alpha 2b-like Protein

External Source Codes: 
PDQ Closed Trial Search ID 703323
PDQ Open Trial Search ID 703323 (check for NCI PDQ open clinical trial info)
NCI META CUI CL430249

Other Properties:
     Name Value (qualifiers indented underneath)
code C97503
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C97503

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