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Version: 17.06d (Release date: 2017-06-26)
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Formestane (Code C974)

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Terms & Properties

Preferred Name: Formestane

Definition: A synthetic steroidal substance with antineoplastic activity. Formestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens. (NCI04)

Label: Formestane

NCI Thesaurus Code: C974 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0048306  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-Hydroxyandrost-4-ene-3,17-dione
4-Hydroxyandrostenedione
4-OHA
4-OHAD
CGP-32349
Formestane
FORMESTANE
Lentaron

External Source Codes: 
CAS Registry Number 566-48-3 (see NLM ChemIDplus info)
FDA UNII Code PUB9T8T355
PDQ Closed Trial Search ID 41766
PDQ Open Trial Search ID 41766 (check for NCI PDQ open clinical trial info)
UMLS CUI C0048306

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C19H26O3
code C974
Contributing_Source FDA
Legacy_Concept_Name Formestane
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C974

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