skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
2-Fluoropropionyl-labeled Pegylated Dimeric RGD Peptide (Code C97336)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: 2-Fluoropropionyl-labeled Pegylated Dimeric RGD Peptide

Definition: A radiopharmaceutical agent comprised of a pegylated dimeric arginine-glycine-aspartic acid (RGD)-based peptide labeled with 2-fluoropropionyl, with potential alphaVbeta3 integrin imaging activity upon positron emission topography (PET). The RGD moiety of 2-fluoropropionyl-labeled pegylated dimeric RGD peptide targets and binds to alphaVbeta3 integrin. Upon PET imaging, alphaVbeta3 integrin-expressing tumor cells can be visualized and expression levels can be quantified. Compared to other fluorine F 18 labeled RGD-containing peptides, this agent shows increased affinity to alphaVbeta3 integrin, enhanced tumor uptake as well as improved pharmacokinetics. alphaVbeta3 integrin, overexpressed on certain tumor cells and tumor endothelial cells, plays a key role in angiogenesis, tumor proliferation and survival.

Display Name: 2-Fluoropropionyl-labeled Pegylated Dimeric RGD Peptide

Label: 2-Fluoropropionyl-labeled Pegylated Dimeric RGD Peptide

NCI Thesaurus Code: C97336 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL429826  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
104150
18F-FP-PEG3-RGD2
18F-FP-PRGD2
18F-FPPRGD2
2-Fluoropropionyl-labeled Pegylated Dimeric RGD Peptide
[18F] FPPRGD2
Fluorine 18 ((18)F) FPPRGD2
PEG3-E[c(RGDyk)]2

External Source Codes: 
PDQ Closed Trial Search ID 703212
PDQ Open Trial Search ID 703212 (check for NCI PDQ open clinical trial info)
NCI META CUI CL429826

Other Properties:
     Name Value (qualifiers indented underneath)
code C97336
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C97336

Mainbox Bottom