skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 16.11d (Release date: 2016-11-28)
SearchBox Top
SearchBox Bottom
Iso-fludelone (Code C97332)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Iso-fludelone

Definition: A third-generation epothilone B analogue with potential anti-mitotic and antineoplastic activites. Iso-fludelone binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. Compared to other generations of epothilones, iso-fludelone exhibits increased stability, water solubility, potency, duration of action, tumor penetration as well as reduced toxicity. In addition, this agent is a not a substrate of the P-glycoprotein (P-gp), a multidrug resistance pump often overexpressed in cancer cells.

Display Name: Iso-fludelone

Label: Iso-fludelone

NCI Thesaurus Code: C97332 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL429824  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
17-Iso-oxazole-26-F3-9,10-dehydro-12,13-desoxy-epothilone B
17-Iso-oxazole-fludelone
Iso-fludelone
KOS-1803

External Source Codes: 
PDQ Closed Trial Search ID 703135
PDQ Open Trial Search ID 703135 (check for NCI PDQ open clinical trial info)
NCI META CUI CL429824

Other Properties:
Name Value (qualifiers indented underneath)
code C97332
Contributing_Source CTRP
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C97332

Mainbox Bottom