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Version: 17.06d (Release date: 2017-06-26)
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Alendronate Sodium (Code C973)

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Terms & Properties

Preferred Name: Alendronate Sodium

Definition: The sodium salt of alendronate, a second generation bisphosphonate and synthetic analog of pyrophosphate with bone anti-resorption activity. Alendronate sodium binds to and inhibits the activity of geranyltranstransferase (farnesyl pyrophosphate synthetase), an enzyme involved in terpenoid biosynthesis. Inhibition of this enzyme prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are donor substrates of farnesylation and geranylgeranylation during the post-translational modification of small GTPase signalling proteins, which is important in the process of osteoclast turnover. As a result, osteoclast activity is inhibited and bone resorption and turnover are reduced.

NCI-GLOSS Definition: A drug used to treat certain bone conditions, such as osteoporosis and Paget disease of the bone. It is also being studied in the treatment of hypercalcemia (high levels of calcium in the blood) and bone pain caused by cancer. Fosamax slows the breakdown of bone and prevents the loss of calcium. It is a type of bisphosphonate.

Label: Alendronate Sodium

NCI Thesaurus Code: C973 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0700482  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Adronat
ALENDRONATE SODIUM
Alendronate Sodium
alendronate sodium
Alendronic Acid Monosodium Salt Trihydrate
Alendros
Binosto
Fosamax
G-704650
MK-217
Onclast

External Source Codes: 
CAS Registry Number 121268-17-5 (see NLM ChemIDplus info)
FDA UNII Code 2UY4M2U3RA
ChEBI ID CHEBI:2566 (see ChEBI info)
PDQ Closed Trial Search ID 41299
PDQ Open Trial Search ID 41299 (check for NCI PDQ open clinical trial info)
UMLS CUI C0700482

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C4H12NO7P2.Na.3H2O
code C973
Contributing_Source FDA
Legacy_Concept_Name Alendronate_Sodium
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C973

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