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Version: 17.06d (Release date: 2017-06-26)
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PI3K/mTOR Kinase Inhibitor DS-7423 (Code C97254)

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Terms & Properties

Preferred Name: PI3K/mTOR Kinase Inhibitor DS-7423

Definition: An orally bioavailable inhibitor of phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinase in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. PI3K/mTOR kinase inhibitor DS-7423 inhibits both PI3K kinase and mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in susceptible tumor cells. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K. Consequently, this agent may potentially be more potent than an agent that inhibits either PI3K kinase or mTOR kinase.

Display Name: PI3K/mTOR Kinase Inhibitor DS-7423

Label: PI3K/mTOR Kinase Inhibitor DS-7423

NCI Thesaurus Code: C97254 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL429785  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
DS-7423
Dual PI3 Kinase/mTOR Inhibitor DS-7423
PI3K/mTOR Kinase Inhibitor DS-7423

External Source Codes: 
PDQ Closed Trial Search ID 701858
PDQ Open Trial Search ID 701858 (check for NCI PDQ open clinical trial info)
NCI META CUI CL429785

Other Properties:
     Name Value (qualifiers indented underneath)
code C97254
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C97254

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