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Version: 17.06d (Release date: 2017-06-26)
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Esorubicin (Code C972)

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Terms & Properties

Preferred Name: Esorubicin

Definition: A synthetic derivative of the anthracycline antineoplastic antibiotic doxorubicin with potential antineoplastic activity. Esorubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. This agent exhibits less cardiotoxicity than the parent antibiotic doxorubicin, but may cause more severe myelosupression compared to other compounds within the anthracycline class.

Label: Esorubicin

NCI Thesaurus Code: C972 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0047760  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4'-Deoxyadriamycin
4'-Deoxydoxorubicin
Deoxyadriamycin
Deoxydoxorubicin
Esorubicin
ESORUBICIN
IMI-58

External Source Codes: 
CAS Registry Number 63521-85-7 (see NLM ChemIDplus info)
FDA UNII Code RMC41L2WQ3
NSC Code 267469 (see NCI DTP info)
PDQ Closed Trial Search ID 39211
PDQ Open Trial Search ID 39211 (check for NCI PDQ open clinical trial info)
UMLS CUI C0047760

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C27H29NO10
code C972
Contributing_Source FDA
Legacy_Concept_Name Deoxydoxorubicin
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C972

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