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Version: 17.06d (Release date: 2017-06-26)
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4'-Iodo-4'-Deoxydoxorubicin (Code C971)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: 4'-Iodo-4'-Deoxydoxorubicin

Definition: An iodinated doxorubicin analogue with antiamyloid activity. 4'-Iodo-4'-deoxydoxorubicin (IDOX) binds with high affinity to five types of natural amyloid fibrils including immunoglobulin light chains, amyloid A, transthyretin (methionine-30 variant), beta-protein (Alzheimer), and beta2-microglobulin. This agent may inhibit fibril growth, increasing the solubility of amyloid tissue deposits and facilitating their clearance. IDOX has also been shown to insulin amyloid fibrillogenesis in vitro.

NCI-GLOSS Definition: A substance that is being studied as a treatment for cancer, and for primary systemic amyloidosis (a disease in which proteins are deposited in specific organs). It belongs to the family of drugs called anthracycline analogues.

Display Name: 4'-Iodo-4'-Deoxydoxorubicin

Label: 4'-Iodo-4'-Deoxydoxorubicin

NCI Thesaurus Code: C971 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0047758  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4'-Deoxy-4'-Iododoxorubicin
4'-Iodo-4'-Deoxydoxorubicin
IDOX
Iodo-Doxorubicin
iododoxorubicin
Iododoxorubicin

External Source Codes: 
CAS Registry Number 83997-75-5 (see NLM ChemIDplus info)
ChEBI ID CHEBI:47897 (see ChEBI info)
NSC Code 378901 (see NCI DTP info)
PDQ Closed Trial Search ID 41162
PDQ Open Trial Search ID 41162 (check for NCI PDQ open clinical trial info)
UMLS CUI C0047758

Other Properties:
     Name Value (qualifiers indented underneath)
code C971
Contributing_Source CTRP
Legacy_Concept_Name _4_Iodo-4_Deoxydoxorubicin
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C971

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