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Version: 17.06d (Release date: 2017-06-26)
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Pentavalent KLH Conjugate Vaccine (Code C97034)

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Terms & Properties

Preferred Name: Pentavalent KLH Conjugate Vaccine

Definition: A pentavalent vaccine comprised of the epitope antigens of the ganglioside lactones GD2L and GD3L, Globo H hexasaccharide 1 (Globo H), fucosyl GM1 and N-propionylated polysialic acid conjugated with the immunostimulant keyhole limpet hemocyanin (KLH), with potential immunostimulating and antineoplastic activity. Vaccination with the pentavalent KLH conjugate vaccine may induce production of IgG and IgM antibodies as well as an antibody-dependent cell-mediated cytotoxicity (ADCC) against tumors expressing any of these antigens. The antigens included in the pentavalent KLH conjugate vaccine are upregulated in a variety of cancer cells. KLH, a natural protein isolated from the marine mollusk keyhole limpet, is an immunostimulant carrier protein.

Display Name: Pentavalent KLH Conjugate Vaccine

Label: Pentavalent KLH Conjugate Vaccine

NCI Thesaurus Code: C97034 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL429641  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Pentavalent KLH Conjugate Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 700447
PDQ Open Trial Search ID 700447 (check for NCI PDQ open clinical trial info)
NCI META CUI CL429641

Other Properties:
     Name Value (qualifiers indented underneath)
code C97034
Contributing_Source CTRP
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C97034

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