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Version: 17.08d (Release date: 2017-08-28)
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Vitamin K1-containing Urea Skin Cream (Code C96802)

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Terms & Properties

Preferred Name: Vitamin K1-containing Urea Skin Cream

Definition: A topical cream containing urea and 0.1% vitamin K1 (phytomenadione) with topical epidermal growth factor receptor (EGFR)-activating activity. Upon application of vitamin K1-containing urea skin cream, vitamin K1 may locally activate EGFR, thereby abrogating EGFR inhibition in the skin caused by systemic EGFR inhibiting agents. This may help inhibit the acne-like skin rash induced by EGFR antagonists. EGFR, a tyrosine kinase, plays a key role in maintaining epidermal integrity.

Label: Vitamin K1-containing Urea Skin Cream

NCI Thesaurus Code: C96802 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL429409  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Reconval K1
Vitamin K1-containing Urea Skin Cream

External Source Codes: 
PDQ Closed Trial Search ID 700245
PDQ Open Trial Search ID 700245 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C96802
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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