skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
HDAC Inhibitor 4SC-202 (Code C96797)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: HDAC Inhibitor 4SC-202

Definition: An orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity. HDAC inhibitor 4SC-202 selectively binds to and inhibits class I HDACs leading to an accumulation of highly acetylated histones. This may result in an induction of chromatin remodeling, the selective transcription of tumor suppressor genes, and the tumor suppressor protein-mediated inhibition of tumor cell division and eventually the induction of tumor cell apoptosis. This may inhibit tumor cell proliferation in susceptible tumor cells. HDACs, upregulated in many tumor types, are a class of enzymes that deacetylate chromatin histone proteins.

Label: HDAC Inhibitor 4SC-202

NCI Thesaurus Code: C96797 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL429405  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4SC-202
HDAC Inhibitor 4SC-202

External Source Codes: 
PDQ Closed Trial Search ID 700110
PDQ Open Trial Search ID 700110 (check for NCI PDQ open clinical trial info)
NCI META CUI CL429405

Other Properties:
     Name Value (qualifiers indented underneath)
code C96797
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C96797

Mainbox Bottom