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Version: 17.06d (Release date: 2017-06-26)
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PARP-1/2 Inhibitor ABT-767 (Code C96795)

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Terms & Properties

Preferred Name: PARP-1/2 Inhibitor ABT-767

Definition: An orally available inhibitor of the nuclear enzymes poly(ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration, ABT-767 selectively binds to PARP 1 and 2, thereby preventing repair of damaged DNA via the base excision repair (BER) pathway. This agent enhances the accumulation of DNA strand breaks and promotes genomic instability eventually leading to apoptosis. ABT-767 may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and can be activated by single strand DNA (ssDNA) breaks.

Label: PARP-1/2 Inhibitor ABT-767

NCI Thesaurus Code: C96795 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL429404  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ABT-767
PARP-1/2 Inhibitor ABT-767

External Source Codes: 
PDQ Closed Trial Search ID 699738
PDQ Open Trial Search ID 699738 (check for NCI PDQ open clinical trial info)
NCI META CUI CL429404

Other Properties:
     Name Value (qualifiers indented underneath)
code C96795
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C96795

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