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Version: 17.06d (Release date: 2017-06-26)
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Netupitant (Code C96745)

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Terms & Properties

Preferred Name: Netupitant

Definition: A selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity. Netupitant competitively binds to and blocks the activity of the human substance P/NK1 receptors in the central nervous system (CNS), thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in the prevention of chemotherapy-induced nausea and vomiting (CINV). SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK-receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema.

Display Name: Netupitant

Label: Netupitant

NCI Thesaurus Code: C96745 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1700730  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-[3,5-bis(Trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide
CID6451149
D05152
Netupitant
NETUPITANT
RO 67-3189/000

External Source Codes: 
CAS Registry Number 290297-26-6 (see NLM ChemIDplus info)
FDA UNII Code 7732P08TIR
PDQ Closed Trial Search ID 699733
PDQ Open Trial Search ID 699733 (check for NCI PDQ open clinical trial info)
UMLS CUI C1700730

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C30H32F6N4O
code C96745
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C96745

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