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Version: 17.12d (Release date: 2017-12-26)
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p.DOM-WT1-37 DNA Vaccine (Code C96737)

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Terms & Properties

Preferred Name: p.DOM-WT1-37 DNA Vaccine

Definition: A fusion DNA vaccine containing the first domain of fragment C (FrC) of tetanus toxin (TT865-1120) (p.DOM) fused to the human Wilms' Tumor gene-1 (WT1)-derived MHC class I-binding epitope WT1.37, with potential antitumor activity. Upon vaccination with p.DOM-WT1-37 DNA and subsequent electroporation, this vaccine may induce a WT1 epitope-specific cytotoxic T-lymphocyte (CTL) response against WT1 expressing cells, resulting in cell lysis and inhibition of cancer cell proliferation in WT1-overexpressing cancer cells. WT1, a tumor associated antigen, is overexpressed in most types of leukemia and in a variety of solid cancers. The FrC of tetanus toxin contains the MHC II-binding sequence, p30, which induces T-helper cell activation for long-lasting immunity.

Label: p.DOM-WT1-37 DNA Vaccine

NCI Thesaurus Code: C96737 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL429362  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
p.DOM-WT1-37 DNA Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 699215
PDQ Open Trial Search ID 699215 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C96737
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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