skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Recombinant B. pertussis Adenylate Cyclase Toxin-Tyrosinase A2 Epitope Vaccine (Code C96735)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Recombinant B. pertussis Adenylate Cyclase Toxin-Tyrosinase A2 Epitope Vaccine

Definition: A recombinant vaccine containing a genetically detoxified adenylate cyclase toxin (CyaA) of Bordetella pertussis coupled, through its catalytic site, to the melanoma tyrosinase A2 epitope YMDGTMSQV, with potential antineoplastic activity. Via the toxin moiety, the recombinant B. pertussis adenylate cyclase toxin-tyrosinase A2 epitope specifically binds to the alphaMbeta2 integrin (CD11b/CD18) located on CD11b-positive antigen-presenting cells (APC). Upon processing and presentation of the melanoma-specific epitope by MHC class I molecules to the surface of these APCs, a specific cytotoxic T-cell (CTL) response against tumor cells expressing tyrosinase may be initiated, resulting in decreased tumor growth and cell lysis.

Label: Recombinant B. pertussis Adenylate Cyclase Toxin-Tyrosinase A2 Epitope Vaccine

NCI Thesaurus Code: C96735 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL429360  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Recombinant B. pertussis Adenylate Cyclase Toxin-Tyrosinase A2 Epitope Vaccine
Recombinant Bordetella pertussis Adenylate Cyclase Toxin-Tyrosinase.A2 Epitope YMDGTMSQV Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 698993
PDQ Open Trial Search ID 698993 (check for NCI PDQ open clinical trial info)
NCI META CUI CL429360

Other Properties:
     Name Value (qualifiers indented underneath)
code C96735
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C96735

Mainbox Bottom