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Version: 17.12d (Release date: 2017-12-26)
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Dichloromethotrexate (Code C966)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Dichloromethotrexate

Definition: A chlorinated methotrexate derivative. Dichloromethotrexate inhibits the enzyme dihydrofolate reductase, thereby preventing the synthesis of purine nucleotides and thymidylates and inhibiting DNA and RNA synthesis. This agent is metabolized and excreted by the liver. (NCI04)

Label: Dichloromethotrexate

NCI Thesaurus Code: C966 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0046764  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
3', 5'-Dichloroamethopterin
Amethopterin, 3',5'-dichloro
Amethopterin, 3',5'-dichloro-
Glutamic acid, N-(3,5-dichloro-4-([(2, 4-diamino-6-pteridinyl)methyl]methylamino)benzoyl)-
Glutamic acid, N-[3,5-dichloro-4-[[(2, 4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-
Glutamic acid, N-[3,5-dichloro-4-[[(2, 4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L- (8CI)
Glutamic Acid, N-{3,5-dichloro-4-{[(2,4-diamino-6-pteridinyl)methyl]methylamino}benzoyl}-
Glutamic Acid, N-{3,5-dichloro-4-{[(2,4-diamino-6-pteridinyl)methyl]methylamino}benzoyl}-L- (8CI)
L-Glutamic acid, N-[3,5-dichloro-4-[[(2, 4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- (9CI)
L-Glutamic Acid, N-{3,5-dichloro-4-{[(2,4-diamino-6-pteridinyl)methyl]methylamino}benzoyl}-(9CI)
Methotrexate, Dichloro
Methotrexate, dichloro-
N-[3,5-Dichloro-4-[(2, 4-diamino-6-pteridinylmethyl)methylamino]benzoyl]glutamic acid
N-[3,5-Dichloro-4-[(2,4-diamino-6-pteridinylmethyl)methylamino]benzoyl] Glutamic Acid

External Source Codes: 
CAS Registry Number 528-74-5 (see NLM ChemIDplus info)
NSC Code 29630 (see NCI DTP info)
PDQ Closed Trial Search ID 39217
PDQ Open Trial Search ID 39217 (check for NCI PDQ open clinical trial info)
UMLS CUI C0046764

Other Properties:
     Name Value (qualifiers indented underneath)
code C966
Legacy_Concept_Name Dichloromethotrexate
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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