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Version: 17.06d (Release date: 2017-06-26)
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2-Methoxyestradiol (Code C965)

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Terms & Properties

Preferred Name: 2-Methoxyestradiol

Definition: An orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endothelial cell apoptosis. This agent also inhibits tumor cell growth by binding to tubulin, resulting in antimitotic activity, and by inducing caspase activation, resulting in cell cycle arrest in the G2 phase, DNA fragmentation, and apoptosis. (NCI04)

NCI-GLOSS Definition: 2ME2. A drug derived from estrogen that belongs to the family of drugs called angiogenesis inhibitors. It prevents the formation of new blood vessels that tumors need in order to grow.

Display Name: 2-Methoxyestradiol

Label: 2-Methoxyestradiol

NCI Thesaurus Code: C965 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0046319  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(17beta)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol
2-MeE2
2-MeOE2
2-Methoxyestradiol
2-methoxyestradiol
2-METHOXYESTRADIOL
2-Methoxy Estradiol
2ME2
Panzem

External Source Codes: 
CAS Registry Number 362-07-2 (see NLM ChemIDplus info)
FDA UNII Code 6I2QW73SR5
ChEBI ID CHEBI:28955 (see ChEBI info)
NSC Code 659853 (see NCI DTP info)
PDQ Closed Trial Search ID 38472
PDQ Open Trial Search ID 38472 (check for NCI PDQ open clinical trial info)
UMLS CUI C0046319

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C19H26O3
code C965
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name _2-Methoxyestradiol
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C965

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