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Version: 17.12d (Release date: 2017-12-26)
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Estrogen Receptor Agonist GTx-758 (Code C96432)

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Terms & Properties

Preferred Name: Estrogen Receptor Agonist GTx-758

Definition: An orally available, nonsteroidal selective estrogen receptor (ER) alpha agonist with potential antineoplastic activity. Upon administration of GTx-758, this agent suppresses the secretion of the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the pituitary gland through feedback inhibition. In males, the inhibition of LH secretion prevents the synthesis of androgens, including testosterone, by the testes. This may result in suppressed total serum testosterone to the levels observed in castration.

Display Name: Estrogen Receptor Agonist GTx-758

Label: Estrogen Receptor Agonist GTx-758

NCI Thesaurus Code: C96432 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3272775  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Estrogen Receptor Agonist GTx-758

External Source Codes: 
PDQ Closed Trial Search ID 698431
PDQ Open Trial Search ID 698431 (check for NCI PDQ open clinical trial info)
UMLS CUI C3272775

Other Properties:
     Name Value (qualifiers indented underneath)
code C96432
Contributing_Source CTRP
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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