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Version: 17.06d (Release date: 2017-06-26)
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Ricolinostat (Code C96431)

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Terms & Properties

Preferred Name: Ricolinostat

Definition: An orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity. Ricolinostat selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation. This leads to an accumulation of unfolded and misfolded ubiquitinated proteins and may eventually induce cancer cell apoptosis, and inhibition of cancer cell growth. HDAC6, a class II HDAC deacetylase located in the cytoplasm, appears to play a key role in the formation and activation of the aggresomes needed for degradation of misfolded proteins. Compared to non-selective HDAC inhibitor, ACY-1215 is able to reduce the toxic effects on normal, healthy cells.

Display Name: Ricolinostat

Label: Ricolinostat

NCI Thesaurus Code: C96431 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3492270  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-(Diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide
ACY-1215
Histone Deacetylase 6 InhibitorACY-1215
Ricolinostat
RICOLINOSTAT

External Source Codes: 
FDA UNII Code WKT909C62B
PDQ Closed Trial Search ID 698408
PDQ Open Trial Search ID 698408 (check for NCI PDQ open clinical trial info)
UMLS CUI C3492270

Other Properties:
     Name Value (qualifiers indented underneath)
code C96431
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C96431

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