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Version: 17.06d (Release date: 2017-06-26)
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Napabucasin (Code C96429)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Napabucasin

Definition: An orally available cancer cell stemness inhibitor with potential antineoplastic activity. Even though the exact target has yet to be fully elucidated, napabucasin appears to target and inhibit multiple pathways involved in cancer cell stemness. This may ultimately inhibit cancer stemness cell (CSC) growth as well as heterogeneous cancer cell growth. CSCs, self-replicating cells that are able to differentiate into heterogeneous cancer cells, appear to be responsible for the malignant growth, recurrence and resistance to conventional chemotherapies.

Display Name: Napabucasin

Label: Napabucasin

NCI Thesaurus Code: C96429 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL429115  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Acetylnaphtho(2,3-b)furan-4,9-dione
BB608
BBI-608
BBI608
Napabucasin
NAPABUCASIN

External Source Codes: 
CAS Registry Number 83280-65-3 (see NLM ChemIDplus info)
FDA UNII Code Z1HHM49K7O
PDQ Closed Trial Search ID 698351
PDQ Open Trial Search ID 698351 (check for NCI PDQ open clinical trial info)
NCI META CUI CL429115

Other Properties:
     Name Value (qualifiers indented underneath)
code C96429
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C96429

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