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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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SarCNU (Code C963)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: SarCNU

Definition: An alkylating chloroethylnitrosourea with antineoplastic activity. Selectively accumulating in some tumor cells, SarCNU forms covalent linkages with nucleophilic centers in DNA, causing depurination, base pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity. (NCI04)

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It is a type of alkylating agent.

Display Name: SarCNU

Label: SarCNU

NCI Thesaurus Code: C963 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0045644  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Chloroethyl-3-Sarcosinamide-1-Nitrosourea
SarCNU
sarCNU
sarcosinamide nitrosourea

External Source Codes: 
CAS Registry Number 92891-93-5 (see NLM ChemIDplus info)
NSC Code 364432 (see NCI DTP info)
PDQ Closed Trial Search ID 43325
PDQ Open Trial Search ID 43325 (check for NCI PDQ open clinical trial info)
UMLS CUI C0045644

Other Properties:
     Name Value (qualifiers indented underneath)
code C963
Contributing_Source CTRP
Legacy_Concept_Name SarCNU
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C963

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