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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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NG-nitro-L-arginine (Code C96232)

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Terms & Properties

Preferred Name: NG-nitro-L-arginine

Definition: An amino acid derivative and nitric oxide synthase (NOS) inhibitor with potential antineoplastic and antiangiogenic activities. Upon administration, NG-nitro-L-arginine inhibits the enzyme nitric oxide synthase, thereby preventing the formation of nitric oxide (NO). By preventing NO generation, the vasodilatory effects of NO are abrogated leading to vasoconstriction, reduction in vascular permeability and an inhibition of angiogenesis. As blood flow to tumors is restricted, this may result in an inhibition of tumor cell proliferation. NO plays an important role in tumor blood flow and stimulation of angiogenesis, tumor progression, survival, migration and invasiveness.

Label: NG-nitro-L-arginine

NCI Thesaurus Code: C96232 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0068821  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
ChEBI ID CHEBI:27960 (see ChEBI info)
PDQ Closed Trial Search ID 697835
PDQ Open Trial Search ID 697835 (check for NCI PDQ open clinical trial info)
UMLS CUI C0068821

Other Properties:
     Name Value (qualifiers indented underneath)
code C96232
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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