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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Parvovirus H-1 (Code C96229)

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Terms & Properties

Preferred Name: Parvovirus H-1

Definition: A replication-competent oncolytic parvovirus with potential antineoplastic activity. Upon infection of host cells, parvovirus H-1 preferentially replicates in tumor cells compared to healthy normal cells, thereby potentially resulting in tumor cell lysis and leading to an inhibition of tumor cell proliferation. In addition, H1-infected tumor cells strongly induce the release of the inducible heat shock protein 72 (Hsp72i), which chaperone tumor associated antigens in the H1-mediated tumor lysates and may activate antigen presenting cells (APCs), thereby leading to antitumor immune responses. Parvovirus H-1 does not cause any pathogenic effect in normal, healthy cells and is able to cross the blood brain barrier (BBB).

Label: Parvovirus H-1

NCI Thesaurus Code: C96229 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0319116  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
H-1PV
ParvOryx
Parvovirus H-1

External Source Codes: 
PDQ Closed Trial Search ID 697624
PDQ Open Trial Search ID 697624 (check for NCI PDQ open clinical trial info)
UMLS CUI C0319116

Other Properties:
     Name Value (qualifiers indented underneath)
code C96229
Semantic_Type Pharmacologic Substance
Semantic_Type Virus

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C96229

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