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Version: 17.06d (Release date: 2017-06-26)
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cFMS Tyrosine Kinase Inhibitor ARRY-382 (Code C96227)

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Terms & Properties

Preferred Name: cFMS Tyrosine Kinase Inhibitor ARRY-382

Definition: A small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; cFMS) with potential antineoplastic activity. cFMS tyrosine kinase inhibitor ARRY-382 binds to and inhibits the activity of cFMS. By preventing colony-stimulating factor-1 (CSF-1)-cFMS signaling, this agent may inhibit tumor cell proliferation in cFMS-overexpressing tumor cells. cFMS, a tyrosine kinase receptor, is overexpressed in certain tumor cell types and plays an essential role in macrophage differentiation and regulation of cell proliferation.

Display Name: cFMS Tyrosine Kinase Inhibitor ARRY-382

Label: cFMS Tyrosine Kinase Inhibitor ARRY-382

NCI Thesaurus Code: C96227 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL429011  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ARRY-382
cFMS Tyrosine Kinase Inhibitor ARRY-382

External Source Codes: 
PDQ Closed Trial Search ID 697525
PDQ Open Trial Search ID 697525 (check for NCI PDQ open clinical trial info)
NCI META CUI CL429011

Other Properties:
     Name Value (qualifiers indented underneath)
code C96227
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C96227

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