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Version: 17.06d (Release date: 2017-06-26)
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Integrin Receptor Antagonist GLPG0187 (Code C96223)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Integrin Receptor Antagonist GLPG0187

Definition: A small molecule integrin receptor antagonist (IRA) with potential antineoplastic activity. Upon administration, GLPG0187 binds to and blocks the activity of 5 RGD-integrin receptor subtypes, including alphavbeta1, alphavbeta3, alphavbeta5, alphavbeta6 and alpha5beta1. This may result in the inhibition of endothelial cell-cell interactions and endothelial cell-matrix interactions, and the prevention of angiogenesis and metastasis in tumor cells expressing these integrin receptors. Integrin receptors are transmembrane glycoproteins expressed on the surface of tumor vessel endothelial cells and some types of cancer cells, and play a crucial role in endothelial cell adhesion and migration.

Label: Integrin Receptor Antagonist GLPG0187

NCI Thesaurus Code: C96223 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL429007  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
GLPG0187
Integrin Receptor Antagonist GLPG0187

External Source Codes: 
PDQ Closed Trial Search ID 697397
PDQ Open Trial Search ID 697397 (check for NCI PDQ open clinical trial info)
NCI META CUI CL429007

Other Properties:
     Name Value (qualifiers indented underneath)
code C96223
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C96223

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