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Version: 16.11d (Release date: 2016-11-28)
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Adenovirus-Encoding E.coli PNP (Code C96221)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Adenovirus-Encoding E.coli PNP

Definition: A replication-incompetent adenovirus encoding E. coli purine nucleoside phosphorylase (Ad/PNP) used as a prodrug activating agent. Administered intratumorally, Ad/PNP expresses the enzyme PNP, which may catalyze systematically administrated fludarabine phosphate prodrug into its active form 2-fluoroadenine (F-Ade). F-Ade inhibits DNA polymerase alpha, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth. Localized prodrug activation provides targeted chemotherapy, thereby potentially reducing systemic side effects.

Display Name: Adenovirus-Encoding E.coli PNP

Label: Adenovirus-Encoding E.coli PNP

NCI Thesaurus Code: C96221 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL429005  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ad/PNP
Adenovirus-Encoding E.coli PNP
Adenovirus Encoding Purine Nucleoside Phosphorylase

External Source Codes: 
PDQ Closed Trial Search ID 697140
PDQ Open Trial Search ID 697140 (check for NCI PDQ open clinical trial info)
NCI META CUI CL429005

Other Properties:
Name Value (qualifiers indented underneath)
code C96221
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C96221

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