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Version: 17.06d (Release date: 2017-06-26)
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Gemcitabine Hydrochloride (Code C961)

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Terms & Properties

Preferred Name: Gemcitabine Hydrochloride

Definition: The hydrochloride salt of an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis.

NCI-GLOSS Definition: A drug used to treat pancreatic cancer that is advanced or has spread. It is also used with other drugs to treat breast cancer that has spread, advanced ovarian cancer, and non-small cell lung cancer that is advanced or has spread. It is also being studied in the treatment of other types of cancer. Gemcitabine hydrochloride blocks the cell from making DNA and may kill cancer cells.

Display Name: Gemcitabine Hydrochloride

Label: Gemcitabine Hydrochloride

NCI Thesaurus Code: C961 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0771488  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-(2-Oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose, hydrochloride
2'Deoxy-2',2'-Difluorocytidine, Hydrochloride
dFdCyd
Difluorodeoxycytidine Hydrochloride
Gemcitabine Hydrochloride
gemcitabine hydrochloride
GEMCITABINE HYDROCHLORIDE
Gemzar
LY-188011
LY188011

External Source Codes: 
CAS Registry Number 122111-03-9 (see NLM ChemIDplus info)
FDA UNII Code U347PV74IL
ChEBI ID CHEBI:31647 (see ChEBI info)
NSC Code 613327 (see NCI DTP info)
PDQ Closed Trial Search ID 41213
PDQ Open Trial Search ID 41213 (check for NCI PDQ open clinical trial info)
UMLS CUI C0771488

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Bladder cancer; Breast cancer; Carcinoma of unknown primary origin; Lung cancer; including non-small cell lung cancer; Ovarian cancer; Pancreatic cancer; Renal cell carcinoma
Chemical_Formula C9H11F2N3O4.HCl
code C961
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Gemcitabine
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C961

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