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Version: 17.06d (Release date: 2017-06-26)
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Anti-OX40 Monoclonal Antibody (Code C96040)

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Terms & Properties

Preferred Name: Anti-OX40 Monoclonal Antibody

Definition: An agonistic monoclonal antibody against receptor OX40 (CD134), with potential immunostimulatory activity. Mimicking the natural OX4 ligand (OX40L), anti-OX40 monoclonal antibody selectively binds to and activates the OX40 receptor. Receptor activation induces proliferation of memory and effector T lymphocytes. In the presence of tumor associated antigens (TAAs), this may promote an immune response against the TAA-expressing tumor cells. OX40, a cell surface glycoprotein and member of the tumor necrosis factor (TNF) receptor family, is expressed by CD4 T cells and provides a costimulatory signal for T cell activation.

Label: Anti-OX40 Monoclonal Antibody

NCI Thesaurus Code: C96040 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL428374  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
anti-OX40 MoAb
Anti-OX40 Monoclonal Antibody

External Source Codes: 
PDQ Closed Trial Search ID 696645
PDQ Open Trial Search ID 696645 (check for NCI PDQ open clinical trial info)
NCI META CUI CL428374

Other Properties:
     Name Value (qualifiers indented underneath)
code C96040
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C96040

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