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Version: 17.06d (Release date: 2017-06-26)
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HER2-targeted Liposomal Doxorubicin Hydrochloride MM-302 (Code C96038)

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Terms & Properties

Preferred Name: HER2-targeted Liposomal Doxorubicin Hydrochloride MM-302

Definition: An antibody-targeted lipidic nano-carrier containing the antineoplastic anthracycline antibiotic doxorubicin encapsulated within liposomes, and conjugated to a monoclonal antibody against the human epidermal growth factor receptor 2 (HER2), with potential antitumor activity. Upon administration of HER2-targeted liposomal doxorubicin hydrochloride MM-302, the immunoliposome allows for specific delivery of doxorubicin to tumors overexpressing the HER2 receptor. Once inside the HER2-expressing tumor cells, doxorubicin intercalates into DNA and interferes with topoisomerase II activity, thereby inhibiting DNA replication and RNA synthesis. Compared to doxorubicin alone or liposomal doxorubicin, targeted liposomal delivery of doxorubicin improves efficacy while lowering the toxicity profile. HER2, a tyrosine kinase receptor, is overexpressed in many cancer cell types.

Display Name: HER2-targeted Liposomal Doxorubicin Hydrochloride MM-302

Label: HER2-targeted Liposomal Doxorubicin Hydrochloride MM-302

NCI Thesaurus Code: C96038 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL428372  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
HER2-targeted Liposomal Doxorubicin Hydrochloride MM-302
MM-302

External Source Codes: 
PDQ Closed Trial Search ID 696572
PDQ Open Trial Search ID 696572 (check for NCI PDQ open clinical trial info)
NCI META CUI CL428372

Other Properties:
     Name Value (qualifiers indented underneath)
code C96038
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C96038

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