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Version: 17.04d (Release date: 2017-04-24)
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VEGFR/PDGFR Dual Kinase Inhibitor X-82 (Code C95896)

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Terms & Properties

Preferred Name: VEGFR/PDGFR Dual Kinase Inhibitor X-82

Definition: An orally available small molecule dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and platelet-derived growth factor receptors (PDGFRs) with antiangiogenic and antineoplastic activities. VEGFR/PDGFR dual kinase inhibitor X-82 inhibits all isoforms of VEGFR and PDGFR, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Both VEGFRs and PDGFRs are receptor tyrosine kinases that may be upregulated in various tumor cell types. VEGFR/PDGFR dual kinase inhibitor X-82 has been shown to reduce tissue toxicity by 95 percent compared with first-generation kinase inhibitors.

Display Name: VEGFR/PDGFR Dual Kinase Inhibitor X-82

Label: VEGFR/PDGFR Dual Kinase Inhibitor X-82

NCI Thesaurus Code: C95896 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL428293  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CM082
VEGFR/PDGFR Dual Kinase Inhibitor X-82
X-82

External Source Codes: 
PDQ Closed Trial Search ID 695817
PDQ Open Trial Search ID 695817 (check for NCI PDQ open clinical trial info)
NCI META CUI CL428293

Other Properties:
     Name Value (qualifiers indented underneath)
code C95896
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C95896

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