skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.12d (Release date: 2017-12-26)
SearchBox Top
SearchBox Bottom
CBP/beta-catenin Antagonist PRI-724 (Code C95894)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: CBP/beta-catenin Antagonist PRI-724

Definition: A potent, specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity. Wnt signaling pathway inhibitor PRI-724 specifically inhibits the recruiting of beta-catenin with its coactivator CBP (the binding protein of the cAMP response element-binding protein CREB); together with other transcription factors beta-catenin/CBP binds to WRE (Wnt-responsive element) and activates transcription of a wide range of target genes of Wnt/beta-catenin signaling. Blocking the interaction of CBP and beta-catenin by this agent prevents gene expression of many proteins necessary for growth, thereby potentially suppressing cancer cell growth. The Wnt/beta-catenin signaling pathway regulates cell morphology, motility, and proliferation; aberrant regulation of this pathway leads to neoplastic proliferation.

Display Name: CBP/beta-catenin Antagonist PRI-724

Label: CBP/beta-catenin Antagonist PRI-724

NCI Thesaurus Code: C95894 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL428291  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CBP/beta-catenin Antagonist PRI-724

External Source Codes: 
PDQ Closed Trial Search ID 696436
PDQ Open Trial Search ID 696436 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C95894
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


Mainbox Bottom