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Version: 16.11d (Release date: 2016-11-28)
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G-Quadruplex Stabilizer BMVC (Code C95893)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: G-Quadruplex Stabilizer BMVC

Definition: A carbazole derivative (3,6-bis[2-(1-methylpyridinium)vinyl]carbazole diiodide) that selectively targets to the G-quadruplex DNA structure, used as a fluorescent probe for cancer cytological diagnosis and with potential antitumor activity. G-quadruplex stabilizer BMVC, preferentially uptaken by cancer cells, binds to and stabilize the telomeric G-quadruplex structure at the end of DNA; when visualized with fluorescent imaging device, BMVC emits bright fluorescent light and can be used to differentiate tumor cells from normal cells. The BMVC/G-quadruplex complexes also interfere with the activity of telomerase, which is highly active in tumor cells and plays a key role in tumorigenesis while expressed at very low levels in most somatic cells.

Label: G-Quadruplex Stabilizer BMVC

NCI Thesaurus Code: C95893 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL428290  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
3,6-bis[2-(1-methylpyridinium)vinyl]carbazole Diiodide
3,6-bis (1-methyl-4-vinylpyridinium) Carbazole Diiodide
BMVC
G-Quadruplex Stabilizer BMVC

External Source Codes: 
PDQ Closed Trial Search ID 696431
PDQ Open Trial Search ID 696431 (check for NCI PDQ open clinical trial info)
NCI META CUI CL428290

Other Properties:
Name Value (qualifiers indented underneath)
code C95893
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C95893

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